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Furthermore, it has been reported that in both animals and humans NNMT expression and activity is enhanced in obesity and related chronic metabolic conditions (e.g., type-2 diabetes)

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Lancet Oncol 23:6576 Mikhael J, Belhadj-Merzoug K, Hulin C (2021) A phase 2 study of isatuximab monotherapy in patients with multiple myeloma who are refractory to daratumumab