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Targeting amino acid metabolism has emerged as a pivotal direction in HCC therapy, primarily through mechanisms that directly inhibit tumor cell proliferation and remodel the immunosuppressive tumor microenvironment

Moreover, signaling pathways commonly associated with stemness, notably the Notch, Hedgehog, and PI3K/AKT/mTOR pathways, intersect with metabolic regulators, forming feedback loops that tightly control energy production, biosynthesis, and cell fate decisions

Preclinical studies have demonstrated that Epithalon activates telomerase in somatic cells through activation of telomerase reverse transcriptase, which promotes telomere elongation, and delays cellular senescence

Available online at: (Accessed September 26, 2025)

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B12 levels increased significantly more for pregnant than non-pregnant women when given an oral dose of 1,000 g (respective increase of 195 vs 117 pmol/l) or 500 g (respective increase of 147 vs 95 pmol/l), but not for 250 g (respective increase of 11 vs