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Moreover, nitric oxide is produced in hypoxic conditions in a respiratory chain reaction, and RNS may trigger reactive species production, such as reactive aldehydes, malondialdehyde (MDA) and 4-hydroxy-2-non-enal (Hussain et al., 2016)

2024;57:21222139.e2129

Archives of Neurology, 63 , 11611164

The implication of oxidative stress and AMPK-Nrf2 antioxidative signaling in pneumonia pathogenesis

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The formation of intermolecular disulfide bonds has been associated with disease-causing misfolded alleles of human 1AT (Ronzoni et al., 2016, Ushioda et al., 2008), raising the possibility that ET might compromise 1AT protein folding