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Blood Cancer J 11:24 Moreau P, Parmar G, Prince M, Ocio E, Karanes C, Madan S et al 2021 A multi-center, Phase 1b study to assess the safety, pharmacokinetics and efficacy of subcutaneous isatuximab plus pomalidomide and dexamethasone, in patients with relapsed/refractory multiple myeloma

While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use

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A Journal of Endocrinology and Metabolism [3] study reported consistent reductions in body fat, improved glucose tolerance, and stable IGF-1 levels

doi:10.1007/BF00275941 134

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