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The disulfide can be reduced by ERdj5 (Ushioda et al., 2016) or selenoprotein N (SEPN1/SELENON) (Marino et al., 2015)

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While NINJ1 has been reported to mediate PMR in several types of lytic cell death [4, 17, 35], our findings indicate that neither ferroptosis induction by erastin nor apoptosis induction by cycloheximide or actinomycin D significantly affected the interaction between NINJ1 and xCT