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11 Risk of PML was found to be concentrated in patients positive for JCV antibodies

Ultraviolet radiation and pollutants in the air can increase the formation of toxic oxygen-containing compounds

Account for this by adding 0.1-0.2 mL extra bacteriostatic water during reconstitution, or simply accept that the last draw from a vial may be slightly less than intended

NAPQI-cys adducts cause oxidative stress, c-Jun N-terminal kinase (JNK) activation and amplification of mitochondrial oxidative stress that can result in mitochondrial membrane permeability transition pore opening, an inability to synthesize ATP and ultimately necrosis 27,28,29,30

Meanwhile, vitamin C itself scavenges ROS in aqueous environments, particularly in the cytoplasm and extracellular fluids

Since Schwann cells require glucose as an energy source, and fatty acids to synthesize myelin