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Mitochondrial transcription factor A (TFAM) is a nuclear gene-encoded mitochondrial transcription factor that binds upstream of the transcription start site and plays an important role in the replication, transcription, assembly, and maintenance of the stability of mtDNA (Zorzano and Claret, 2015), increasing the flexibility of DNA and promoting its compression (Malarkey et al., 2016)

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Chronic inflammation, poor blood flow, and scar tissue often create a hostile environment that halts this regeneration entirely

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Treatment of cobalamin deficiency After diagnosing cobalamin deficiency, a supplement may be prescribed with the aim of restoring appetite and well-being, allowing weight gain, and promoting normalisation of blood cell abnormalities