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At night and during darkness, the activity of post-ganglionic sympathetic fibers increases, which leads to the release of norepinephrine (NA) into the pineal gland, where it binds to pinealocyte -AR receptors increasing intracellular cAMP, which is responsible for the phosphorylation of CREB protein, a transcription factor initiating SNAT genes transcription (23, 24)

Unlike LSD1, LSD2 requires an extended region of the H3 tail for substrate recognition 154

* Correspondence: Xiyun Wang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Gut flora in health and disease