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Remarkably, however, deletion of -glutamyl cysteine synthase (GSH1), which catalyzes the first, rate-limiting step in GSH biosynthesis, cannot be complemented by the Trx system, and gsh1 deletion mutants require exogenous GSH supplementation for growth [155,156]

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The flavonoid baicalin (Figure 2G) is one example

J Hortic Sci Biotechnol 79:528532

Thus, ferroptosis can be defined as a non-apoptotic mode of regulated cell death, driven by iron accumulation and membrane lipid peroxidation when GPX4 activity is inhibited (Fig