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Sequences targeting GCDH (RefSeq ID: 2639) were identified using VBC-Score, and the top three hits were cloned into the pKLV-U6sgRNA pGK Puro-2A-BFP vector (Addgene, 50946) using BbsI cloning

Diabetes Care 33 , 15851590 (2010)

DSIP is the only peptide in this list whose primary mechanism is directly tied to sleep architecture rather than using sleep as a secondary output

Unlike the other compounds catalogued here, 5-Amino-1MQ is not a peptide

It works by blocking signals in the brain that trigger these symptoms

Diuretics can cause decreased arterial responsiveness to vasopressor amines (e.g., norepinephrine), but the effect is not sufficient to preclude their coadministration