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There are similarities, but also some important differences

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Comparing the MSCs-treated and EXOs-treated groups to the untreated POI mice, the former showed restored blood hormone levels and estrous cycles

The following relevant parameters were determined where possible: area under the concentration-time curve from time zero to the last time point (AUC 0-last ) or extrapolated to infinity (AUC 0- ), C max concentration in plasma extrapolated to time zero (C 0 ), terminal elimination half-life (t 1/2 ), volume of distribution (Vd), and clearance (CL)