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Additionally, ferulic acid can significantly reduce seizure intensity, myoclonic spasms, and cognitive decline in epileptic mice (Lenzi et al., 2015), and can reduce the Bax/Bcl2 ratio in dopaminergic neurons in the striatum in mice with Parkinsons disease (PD) (Hassanzadeh et al., 2017)

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Main reasons for changes in therapy are side-effects and insufficient therapy response, which highlight the importance of regular follow-up and screening for side-effects

However, blood sampling is invasive, requires trained personnel, and represents only a narrow detection window

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