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The density of these cells positively correlates with the severity of tau pathology, and their clustered aggregation is often a harbinger of neuritic plaque formation (149, 150)

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The LC separation employed a gradient of solvent B (0.1% FA in 98% acetonitrile) from 6% to 22% over 22 min, followed by an increase to 36% over 8 min, and a final ramp to 80% over 5 min, which was maintained for 3 min

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doi: 10.1073/pnas.2017364118 36 KankanamgeD.RatnayakeK.SamaradivakaraS.KarunarathneA

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References Cuellar-Bermudez SP, Aguilar-Hernandez I, Cardenas-Chavez DL, Ornelas-Soto N, Romero-Ogawa MA, Parra-Saldivar R

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