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To date, there is no evidence of hepatotoxicity, nephrotoxicity, or cardiac damage in any animal trialseven when administered in extremely high doses

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Systemic adverse effects appear to be uncommon based on available reports, but comprehensive adverse event profiles are lacking due to the paucity of large-scale clinical investigations

According to the median serum B vitamin levels of breast cancer patients, divide them into different subgroups, analyze the B vitamin levels and age, menstrual status, age at menarche, family history of breast cancer, BMI, TNM staging of breast cancer patients, Tumor size, lymph node status, expression of ER and PR, Ki-67, Her-2, Androgen Receptor (AR), pathological type, surgery, chemotherapy and other baseline characteristics

Levothyroxine (T4) is a synthetically prepared levo-isomer of thyroxine, a hormone secreted by the thyroid gland