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10.1016/j.tvjl.2012.05.027

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In one melanoma study, mice exposed to higher NAC doses experienced greater metastatic activity than those given lower doses, suggesting the effect may be dose-dependent in certain experimental settings.42 Researchers have not established whether these findings apply to humans, but starting with a moderate dose offers a more conservative approach while still aligning with a large portion of the clinical literature

In contrast, another study showed that in BC patients receiving neoadjuvant chemotherapy, high ACSL4 expression could serve as an independent predictive factor of a better pathological complete response and better overall survival, revealing the controversial role of ACSL4 in the response to chemotherapeutic drugs

Peer review Peer review information Communications Medicine thanks Lei Guo and Woo Ri Chae for their contribution to the peer review of this work

Gastroenterology 140 (1), 210220