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Alkaloids play a crucial role in pharmacology, with indole-containing alkaloids, such as alkaloid N-glycoside, berberine, and piperine, being particularly significant in medicinal chemistry due to their chemical reactivity and diverse pharmacological activities [109]

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Lets back up a little bit and ask, why would researchers be heat-treating living bacteria to kill them when its always been thought that to be active a probiotic product must contain viable live cultures