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Conversely, glutathione reductase (Gsr), heme oxygenase 1 (Hmox1), glucose transporter member 5 (Glut5) and lipoprotein lipase (Lpl) were increased during the dark, or active period, suggesting that microglia have increased nutrient uptake during the active period

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Further, altered histone deacetylation has been shown to affect key pathways involved in neuroinflammation and dopaminergic neuron survival, contributing to disease progression

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HGF/c-met signaling pathway in metastatic process The c-Met, and its ligand HGF have been associated with tumor formation and progression to metastasis, with MET gene often overexpressed or mutated

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The study did not demonstrate conventional immediate pharmacological sedation, and the authors proposed that DSIP might influence sleep regulation rather than act like a standard hypnotic medicine

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