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The demonstration that the oxidative stress associated with mycotoxins can be related to direct suppression of GCLC gene function, post-translational modification of Nrf2 or the presence of excess TGF- suggests that the lack of glutathione may be due to the inability of mycotoxin-affected cells to adequately form glutathione

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Although there are multiple trials to test the efficacy of PFD in humans for IPF treatment, only four phase III clinical studies of PFD in IPF have been completed and reported (Liu et al., 2017a)