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Nevertheless, it is important to note that many studies demonstrating 3-HK cytotoxicity employ supraphysiological concentrations [157], underscoring the need to define pathologically relevant exposure levels in depression

Heparinized whole blood was collected for estimation of enzyme RBC superoxide dismutase, RBC glutathione peroxidase while serum was used for estimation of lipid peroxide

doi: 10.3389/fphar.2025.1362060 Received 27 December 2023 Accepted 13 January 2025 Published 06 February 2025 Volume 16 - 2025 Edited by Thakur Uttam Singh, Indian Veterinary Research Institute (IVRI), India Reviewed by Yuxiang Fei, China Pharmaceutical University, China David Cruz Robles, National Cardiology Institute Ignacio Chavez, Mexico Updates Copyright 2025 Fan, Hu and Shi

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Parkinsonism and tremor syndromes

Thus, experiments with ovariectomized (OVX) rats have shown a reduction in the anti-oxidant activity of superoxide dismutase (SOD) in the hippocampus, a process that contrasts with an increase in the pro-oxidant enzyme monoamine oxidase (MAO) in the same region (Huang and Zhang, 2010)