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Since there are deficiency alleles with mutations outside the coding sequence and there are individuals with three mutations, it is not possible to assume that all coding region mutations are responsible for the disease

Bile salts are the predominant organic solutes in bile

10.3389/fphys.2019.00411 62 YanM.ChenK.HeL.LiS.HuangD.LiJ

[194] Importantly, the specific and often heterogeneous contexts surrounding genetic targets during the screening process may complicate clinical translation of preliminary findings

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A randomized clinical trial on the use of selenium in patients with mild GO provided evidence for a beneficial effect