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PMID: 39755015 Proc Natl Acad Sci U S A2026 Apr 14;123(15):e2520128123

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Probl Cardiol

Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway

Among the various compounds synthesized, the alkyl-based PROTAC 73 stands out, capable of inducing in vitro a selective and potent proteasome-dependent degradation of the target protein (DC 50 value of 214 nM), resulting in a favorable antiproliferative effect (IC 50 value of 1.3 M) 128