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All source data underlying the graphs presented in the main figures are provided as Supplementary Data 1

The Polygonum cuspidatum extract markedly suppressed the production of COX-2, IL-6, and TNF-, as well as the activation of NF-B p65 in hyperosmolar stress-induced HCECs

Parent precursor masses of 124.0, 399.3, 385.1, and 665.1 Da and Q3 masses set to m/z 80.0, 250.1, 136.0, and 136.0 were used for the quantitation of NA, SAM, SAH, and NAD+, respectively