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Furthermore, it has been found that degradation of transcription factors such as nuclear erythroid 2 related factor (Nrf2) decreases expression of many antioxidant enzymes

(I) Des--carboxy prothrombin (DCP) is secreted from HCC cells and activates c-Met because it contains two structural regions that are similar to HGF (Suzuki et al., 2005

However, the waking up time still needs to be monitored

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A previous study suggested that excessive oxidative stress-induced impaired autophagic flux is a key pathogenic event in DED (Wang et al., 2021)

In many cases radio diagnosis like CT scan, MRI, Autopsy of brain, have shown lower iron levels in substantia nigra which is evidence for PLMS and RLS pathology [28]