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Such findings suggest that inadequate ROS production impairs mucosal immunity, allowing pathogenic bacteria to persist and leading to chronic inflammation

Impairing SUMOylation halts CCA growth and, thus, may represent a potential novel therapeutic strategy for patients with CCA for whom current targeted therapies are limited

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Leukemia 36 (6), 15851595

Each gRNA sequence was 20 nucleotides in length and directly upstream of the protospacer adjacent motif (PAM) 5-NGG-3