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If your skin is sensitive or not used to active products, start using it gradually and monitor the skins response, especially because it contains Retinol and some essential oils

Experimental evidence has demonstrated that TXNIP inhibits Trx1 activity, thereby promoting ferroptosis

2 Iliopoulos DC, Kritharis EP, Boussias S, et al

Lancet (2016) 388(10055):202338

its presence in endothelial cells of the blood-brain barrier may contribute to the maintenance of concentration of ascorbate in the brain (Li and Schellhorn, Mechanisms of entry into enterocytes Both ascorbate and DHA can enter enterocytes via SVCT and GLUT transporters, respectively