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It is well known that the disease tends to further worsen becoming chronic with complications, if PCOS patients are left untreated

Oxidation treatment can rearrange the cell cytoskeleton structure (actin and vimentin) (54,102), increase the synthesis of ECM (fibronectin, plasminogen activator inhibitor 1, connective tissue growth factor) (103), decrease the adhesion to ECM (fibronectin, laminin, collagen types I and IV) (54), and increase the expression of some inflammatory mediators [interleukin (IL)-1, IL-6, IL-8 and endothelial-leukocyte adhesion molecule 1 (ELAM-1)] (57,103), leading to cell apoptosis and death (100)

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