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Additionally, estrogens seem to be necessary for axonal growth and synaptic plasticity (Kretz et al., 2004

Because of their control over oxidative stress-related ageing and apoptosis, mitochondria are considered a dominant source of ROS [14]

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In summary, as a critical component in AD pathology, mechanistic investigation and therapeutic exploration of ferroptosis hold significant importance, necessitating further multidimensional and interdisciplinary research to comprehensively understand its relationship with AD and drive innovative treatment development

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