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Hepatic fibrogenesis Iron-induced liver cell injury results in the release of cell damage-associated cytokines, chemokines, and proinflammatory mediators, which leads to hepatic inflammation [84], the activation of hepatic stellate cells into pathological collagen-producing myofibroblasts, and ultimately hepatic fibrosis, cirrhosis, and liver cancer [77]

In AD, mitochondrial transport is compromised: dynein/kinesin dysfunction, caused by A oligomers inhibiting motor proteins, prevents mitochondria from moving along axons and dendrites

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