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The effectiveness data available to date together with the basic biology studies most certainly warrant further research into this compound in the conditions discussed here and in clinical scenarios reviewed elsewhere [6]

However, the use of L-carnitine-containing preparations is not limited to sports nutrition, but can also be used for geriatric purposes and as general nutritional supplements

For example, L-carnitine is removed from the circulation during hemodialysis

Times vary (weeks to months) and effects can be modest or not perceived

While CKD is known to alter the gut microbiome, there is mounting evidence to suggest that TMAO is not only a biomarker for CKD, but also contributes to disease progression This points to diet, microbiome, hepatic TMA metabolism, and TMAO behavior as potential therapeutic targets

Exp Gerontol 56:142146 Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis