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The parameters used in the GAPIT model were KI = NULL, PCA.total = 3, SNP.MAF = 0.02, SNP.fraction = 0.6, Major.allele.zero = TRUE and Geno.View.output = FALSE

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In good alignment, HIF-1 formed during hypoxia inhibits fatty acid -oxidation, which is critical for cancer progression 311,312 , further resulting in lipid droplet accumulation commonly observed in many solid tumors 295