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64 In a randomized, double-blind pilot study that assessed the impact of adding silymarin (420 mg/day) to standard chemotherapy on the clinical response of advanced malignancies following three cycles of cisplatin-based chemotherapy, a tendency of decreased metastasis rate in the chemotherapy plus silymarin group was reported though there was no significant variance in tumor size

& Muller, H

FEMS Microbiol Lett 219:187194 Lagrain B, Thewissen BG, Brijs K, Delcour JA (2007) Impact of redox agents on the extractability of gluten proteins during bread making

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While this often leads to desired effects such as long-lasting activity, it can also give rise to significant issues later in the drug discovery pipeline, e.g

True enzymatic rates were obtained by subtracting the non-enzymatic rates (no enzyme present) from the total rates given by these experiments