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doi: 10.1146/ANNUREV-MED-042320-021020 70

A 2021 meta-analysis of the SUSTAIN and PIONEER trialsthe clinical trial programs used to assess semaglutides effectiveness in people with Type 2 diabetesfound that semaglutide use increased deep vein thrombosis (DVT) by 266%

Conservative stacking protocols start with lower tirzepatide doses (510mg weekly) and moderate 5-amino-1MQ doses (50mg daily) to minimize additive metabolic stress while monitoring tolerability

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