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Because spermidine is not only obtained from the diet but is also endogenously synthesised and produced by the gut microbiota, the total polyamine pool reflects the combined contribution of all three sources, making it difficult to detect a shortage from any single source, and therefore true dietary depletion conditions are unlikely to occur 9

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Kuo A, Lee MY, Sessa WC

raw dried ripened fruit) was recorded as early as the Annotation of Materia Medica and is mainly used to treat anorexia, hyperlipidemia, hypertension, and other diseases in the clinic

2016 Apr 20

HA-CS nanocomplexes loaded with siRNA could penetrate the rabbit vitreous, and following intravitreal injection, a reduction in laser-induced neovascularization in the rabbit retina was observed, accompanied by good tolerability, biosafety, and enhanced bioavailability [32]