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In addition, some studies have shown that zingerone can reduce the expression of inflammatory factors such as PGE, NO, COX-2 and malondialdehyde (MDA) (oxidative stress index) and play an anti-inflammatory role [38]

ISA was also identified as a strong stimulator of glucose uptake in L6 rat skeletal muscle cells: at concentrations below 5 M that does not affect the viability, ISA can obviously enhance the basal glucose uptake (Arha et al., 2018)

The other reason is that its mild and works very well combined with other cleansing agents and surfactants

Tonelli C, Chio IIC, Tuveson DA (2018) Transcriptional regulation by Nrf2

One major challenge is enzymatic heterogeneity within the tumor microenvironment, which can affect prodrug activation efficiency

Can also have a lightening effect to the skin