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Conditions associated with elevated B12 levels include: Liver disease : Hepatocellular damage releases stored B12 into circulation, with levels correlating with disease severity in conditions such as cirrhosis, hepatitis, and hepatocellular carcinoma Renal impairment : Reduced kidney function decreases B12 clearance, leading to accumulation Haematological malignancies : Myeloproliferative disorders, acute leukaemia, and polycythaemia vera can elevate B12 through increased production of B12-binding proteins (transcobalamins) Solid tumours : Certain cancers, particularly those affecting the liver or gastrointestinal tract, may elevate B12 levels A specific concern relates to cyanocobalamin in patients with Leber's hereditary optic neuropathy , a rare mitochondrial disorder

Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats

J Mol Cell Biol 11(4):330341 Fatima I, El-Ayachi I, Playa HC et al (2019) Simultaneous multi-organ metastases from chemo-resistant triple-negative breast cancer are prevented by interfering with WNT-signaling

A m J Respir Crit Care Med

The System: An HPLC system consists of a solvent reservoir, a high-pressure pump, an injector, a column, and a detector

10.1007/s11033-022-07673-x 67 MehtaV.SumanP.ChanderH