glutathione production 3q21.3 Bio-based production: Microbial strategies and challenges Glutathione precursor amino acids, permeases

However, while the collapse of the GSH/GPx4 axis and iron dysregulation are well-documented hallmarks of FXN deficiency, the precise involvement of other canonical ferroptotic nodes, such as the ferroptosis suppressor protein 1 (FSP1)/dihydroorotate dehydrogenase (DHODH) rescue pathways, NCOA4-mediated ferritinophagy, and ACSL4-driven lipid remodeling, remains largely inferred

It is positively correlated with zinc accumulation, thereby conferring a protective effect against excess zinc-induced cytotoxicity

GR activity increased in LT + GSH treated plants involving G1C, G2C and G3C by 3.5 fold, 4.4 fold and 4.2 fold, respectively when compared to LT only

Abstract Heavy metals (HMs) such as lead (Pb) pose a significant threat to global food security due to their adverse effect on the health of crop plants

Gatidis S, Zelenak C, Fajol A, Lang E, Jilani K, Michael D, et al

In conclusion, the metabolism of many amino acids (including Cys, Met, etc.) is involved in the regulation of iron death, which may be a new target for the treatment of iron death-related diseases