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Clin Chim Acta 348(12):131137

doi: 10.1016/j.molcel.2021.12.001 12 NagataS

To our knowledge, this is the first study to perform transcriptomic profiling on metformin treated SW837 rectal cancer cells, and supports a previous study in colon cancer cells, demonstrating metformin-induced alteration of genes involved in reactive oxygen species production, cell cycle, programmed cell death and energy metabolism pathways (68)