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Disclosure of Information 4 types of disease variations: Minima: deletion of 1 gene Gene A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms

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These diseases encompass a wide spectrum of conditions, including HCC, NAFLD, ALD, viral hepatitis, and cirrhosis

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Notably, supplementation with ferrostatin-1 or trolox, both of which are radical-trapping antioxidants and potent inhibitors of ferroptosis, rescued survival but not proliferation under cystine-free conditions (Extended Data Fig

10.1016/j.pcad.2023.02.006 54 DorlingJ