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Cell Signal 51:110118

Its primary job is to combat oxidative stress by neutralizing harmful free radicals unstable molecules that can damage cells, proteins, and DNA

doi: 10.1016/j.bbamem.2017.04.006 73 SharmaPSinghR

AOP Development Strategy Context Used to provide background information for AOP reviewers and users that is considered helpful in understanding the biology underlying the AOP and the motivation for its development.The background should NOT provide an overview of the AOP, its KEs or KERs, which are captured in more detail below

Notably, lung cancer stem cells maintain a distinct metabolic profile by upregulating BCAA transporters, which may contribute to therapy resistance [32,33,34]

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