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Deficient O-glycosylation compromises mucin production and disrupts the mucus barrier, thereby facilitating inflammasome activation (e.g., caspase-1, IL-1, IL-18) and exacerbating inflammation

Han R, Chen X, Li Y, Zhang S, Li R, Lu L

Kinetics analyses were performed using FlowJo v8.1

Summary Glutathione as our primary antioxidant is critical for health

Scientists have also learned how to develop synthetic peptides (lab made versions), which have been designed to mimic or enhance these natural functions in the body

Basket trials Type of clinical trial that evaluates efficacy of a targeted therapy across multiple different diseases or conditions (for example, testing a novel therapy in both Crohns disease and ulcerative colitis within the same protocol)