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Erastin-induced ferroptosis via the Xc-mediated ROS/P38-MAPK pathway feedback loop presents novel strategies for comprehensive treatment of GC [97]

Front Physiol 12:680544 Deng F, Zhao BC, Yang X et al (2021) The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis

The foam cells secrete inflammatory substances that promote the production of a tough fibrous matrix that caps the fatty core to generate a plaque

(2006) detected S-nitrosylated PDI aggregates in the brains of patients with AD and PD, suggesting that NO-mediated impairment of ER proteostasis contributes to neurodegeneration

Using a combination of RNAseq and metabolomics analysis of mouse liver samples taken 3 h and 6 h after introduction of dietary MR, in conjunction with in vitro analysis of methionine-restricted HepG2 cells, our data suggest that the rapid initial decrease in hepatic methionine decreases ternary complex formation, slows overall translation, and induces an ISR that is modulated by mTOR, Erk1/2, and ATF4