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Melanoma cell lines with single resistance to Vemurafenib (BRAF inhibitor) and double resistance to Vemurafenib/Selumetinib (MEK inhibitor)exhibit increased glutamine uptake and NH4+ production without changes in glucose uptake (158)

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Our data show that suppressing production of NADPH leaves the ER more oxidizing (or, to be more precise, more resistant to reduction) and, consequently, more resistant to an exogenous ER stressor (Gansemer et al., 2020)