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Ronis MJJ, Huang J, Crouch J, Mercado C, Irby D, Valentine CR, Lumpkin CL, Ingelman-sundberg M, Badger TM: Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentration in rats

Moreover, patients with progressive ALD have stage 3-4 fibrosis, yet there remains no effective antifibrotic therapies available for patients with fibrosis