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In a strain of spontaneously hypertensive rat, high zinc levels in erythrocytes and heart muscles were found, and zinc deficient diet could facilitate the development of hypertension likely through oxidative stress 64

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The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

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[DOI] [PubMed] [Google Scholar] Woodlock TJ, Brown R, Mani M, Pompeo L, Hoffman H, Segel GB, et al

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