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While this explanation touches on some interesting concepts, there are several points that need clarification and might be oversimplified or speculative: Lets start with neuronal compensation

Older people or those with long-term illnesses might notice slower progress because their metabolism works

It's a question of whether oral dosing produces pharmacokinetic consistency suitable for research goals

Researchers tracking progress with DEXA scans or bioimpedance analysis generally observe significant changes by week 812 of combination protocols

Clinical trials used doses of 0.3 4.5 mg/week, at a 2.5 mg/ml concentration, a 2.4 mg dose = 0.96 ml = 96 IU on the insulin syringe

21, 23 Consider supplementation when the patient is prescribed medications causing folate deficiency, e.g., methotrexate