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As far back as the 1970s, tobacco companies researched nicotine analogs such as 6-methylnicotine to try to find molecules that might be more desirable for users and avoid future regulations

The association between smoking rates and tobacco advertisements has been previously studied, and the increase in the use of e-cigarettes in Western countries has been attributed to media promotion [31]

These findings hold implications for addressing the mental health challenges faced by adolescents via policy measures, particularly regarding the diverse activities engaged in by adolescents, such as exposure to secondhand smoke in various public settings, which can influence the prevalence of anxiety 22

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