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Immunofluorescence staining and western blot results verified that GPX1 expression was absent in the cochlear SGNs of gpx1 / mice (Supplementary Figures 1A,C), and there was no significant difference in SGNs number between the gpx1 / mice and WT mice (Supplementary Figure 1B), which indicated that the absence of GPX1 in normal SGNs would not affect the survival of SGNs

39 Oxidative stress changes mitochondrial dynamics In resemble to ROS production and elimination, the mitochondrial dynamics between fusion and fission are in equilibrium

This concept, proposed in the Azalea Hypothesis by Steve LeVine [43] , suggests that despite appearing iron overloaded, cells may be unable to access usable iron for mitochondrial processes (Figure 2)

162 Quit Smoking The risk of CKD progression is higher in current and past smokers than in people who never smoked

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10.1155/2017/9574201 Oxid