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This may include zinc, B6/P-5-P, vitamin D, methionine or SAMe when appropriate, creatine, antioxidant support, copper-lowering strategies, protein correction, or treatment of elevated SAH and toxic burden

Muscle mass as a fraction of body weight decreases with age, which is why age appears in the Cockcroft-Gault equation

This not only directly chelates toxic metals and quenches free radicals to affect biological systems but also indirectly regenerates endogenous antioxidants to enhance cellular antioxidant defense mechanisms [121]

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Studies indicate that it exerts multi-target effects on glucose and lipid metabolism by modulating blood glucose and lipid levels, optimizing insulin secretion, improving cortisol profiles, and restoring vascular endothelial function