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SeNPs overcome the narrow therapeutic window of aqueous Se, offering reduced systemic toxicity, demonstrated to be up to 10-fold lower in animal models, while maintaining or enhancing biological efficacy

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The cytokines secreted by Th1 and Th17 cells (e.g., IFN- and IL-17) can directly act on hepatic stellate cells, stimulating their activation and proliferation, which leads to the synthesis of extracellular matrix components like collagen and contributes to liver fibrosis [101, 102]

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In summary for LCMS single and tandem/hybrid MS systems, TQ MS (MRM mode) ranks first, followed by TOF MS and then single quadrupole MS (SIM) mode in terms of quantitative analysis performance (e.g