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10.15252/embr.201948978 52 JungT.GruneT

Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K

However, in FUS-induced ALS/FTD, FUS is hypomethylated and accumulates in neurons as both nuclear and cytoplasmic aggregates

Dysregulation of PGC-1, a master regulator of mitochondrial metabolism, leads to increased neuronal vulnerability

StenvallJ.Fierro-GonzalezJ

Typically, E3s recognize substrates that are modified, often by phosphorylation (for more details, read Zheng & Shabek and Shabek & Zheng and Shabek & Ciechanover)